Translation alterations in Parkinson´s disease

DJ-1 inhibits PTEN, a negative regulator of PI3K/Akt signaling and also binds to certain mRNA transcripts in a manner that inhibits their translation. TORC1 activity may contribute to PINK1/Parkin pathology potentially through mRNA translation. Mutations in the translation initiation factor eIF4G1 likely cause PD. Additionally, LRRK2 stimulates mRNA translation through interaction with the ribosome and phosphorylation of s15. Hence, tightly regulated translation is crucial for cellular function and survival and loss of this control may predispose to disease (1).

Reference

1. Martin I. Decoding Parkinson’s Disease Pathogenesis: The Role of Deregulated mRNA Translation. Journal of Parkinson's Disease. 2016;6(1):17-27.

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